PDGFR Bta (pY1021) PE J105-412 50Tst
货号：
558417 基本售价：
3675.0 元 规格：
50Tst
产品信息
概述| 货号 | 558417 |
| 描述 | Platelet-derived growth factor (PDGF) is a potent mitogen for cells of mesenchymal origin and exerts its effects by binding to the PDGF receptor (PDGFR), a transmembrane protein tyrosine kinase. PDGFR is composed of PDGFRα (CD140a) and/or PDGFRβ (CD140b) polypeptides. Both PDGF and PDGFR consist of subunits that form homo- or heterodimers with varying specificities: PDGF-AA binds only to αα PDGFR, PDGF-AB binds to both αα and αβ PDGFR, and PDGF-BB binds to all three PDGFRs . Ligand binding induces dimerization and activation of the receptor. Upon activation, CD140b is phosphorylated at multiple tyrosine sites and, in turn, an intracellular phosphorylation cascade is initiated. PDGFR localizes primarily to membrane invagin ations termed caveolae, compartments that are enriched in several of its downstream effectors, including phosphatidylinositol 3-kinase, Src, and phospholipase C-γ (PLC-γ). The J105-412 monoclonal antibody recognizes the phosphorylated tyrosine 1021 (pY1021 ) in the C-terminal noncatalytic region of CD140b, which interacts primarily with PLC-γ. The orthologous phosphorylation site in mouse PDGFRβ is Y1020. |
| 别名 | PDGF Receptor β |
| 同种亚型 | IgG1,κ |
| 反应种属 | Mouse (QC Testing) Human (Reactivity Confirmed in Development) |
| 来源宿主 | Mouse |
| 使用方法 | IC/FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human PDGFRβ (pY1021) |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
