Akt Pure 2/PKBa/Akt 50ug
货号：
610876 基本售价：
3312.0 元 规格：
50ug
产品信息
概述| 货号 | 610876 |
| 描述 | Protein Kinase B (PKB), also known as Rac ( R elated to the AandC kinases) Protein Kinase, shows 73% and 68% to Protein Kinase C (PKC) and Protein Kinase A (PKA), respectively. It was also identified as the product of the v-akt oncogene from T-cell lymphomas. Akt/PKB mRNA has been reported to be expressed in a wide variety of cell lines and has been detected in porcine brain, heart, liver, kidney, muscle, and ovary. Rac phosphorylates a number of physiological substrates including MBP, glycogen synthetase, PKA RII subunit, and histone H1. Akt/PKB is activated in response to growth factors through the activation of PI3-kinase and Ras. Activation of PI3-Kinase generates phosphatidylinositol 3,4-bisphosphate which may induce the membrane translocation of Akt/PKB coincident with its phosphorylation and activation. Cellular stress leading to the activation of the p38 MAP kinase also induces Akt/PKB activation, indicating a multiplicity of signaling pathways that activate Akt/PKB. Upon activation, Akt/PKB associates with some members of the PKC family of kinases, such as PKC δ and PKC ζ . Downstream of Akt/PKB, GSK3 is thus far the only identified substrate for Akt/PKB phosphorylated in vivo. |
| 别名 | PKBα; RAC-PK |
| 同种亚型 | IgG2a |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog, Fly (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human PKBα/Akt1 aa. 1-480 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
