mTOR (pS2448) PE O21-404 50Tst
货号：
563489 基本售价：
2695.0 元 规格：
50Tst
产品信息
概述| 货号 | 563489 |
| 描述 | The O21-404 monoclonal antibody recognizes the human mammalian target of rapmycin,(mTOR) that is phosphorylated at serine residue 2448, mTOR (pS2448). mTOR belongs to the phosphoinositide-3-kinase (PI3K)-related (PIKK) family of kinases. mTOR is also known as mechanistic target of rapamycin (serine/threonine kinase), FRAP, RAFT1, and RAPT1. mTOR functions as an amino acid and ATP sensor to balance nutrient availability and cell growth. When nutrients are sufficiently available, mTOR is activated by phosphorylation at serine residue 2448 through the PI3 kinase/Akt signaling pathway. Phosphorylated mTOR in turn activates the p70 S6 kinase and contributes to the inactivation 4E-BP1, an elF4E inhibitor. In this way, mTOR participates in the upregulation of cellular protein synthesis, growth, proliferation and survival. mTOR function may be abnormally regulated in tumors. |
| 别名 | Mammalian target of rapamycin; FRAP1; RAFT1; RAPT1 |
| 同种亚型 | Mouse IgG1, κ |
| 反应种属 | Human (QC Testing) Mouse, Rat (Predicted) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Peptide |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
