INF-α Secretion Assay Enrich/Det Kit PE
货号：
130-092-605 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-092-605 |
| 描述 | The IFN-α Secretion Assay – Cell Enrichment and Detection Kit was developed for the sensitive detection as well as the enrichment of human IFN-α–secreting cells. |
性能| 供应商 | Miltenyi |
| 背景 | Type I interferons (IFNs), including IFN-α, are a family of cytokines that have pleiotropic functions in the immune system.1 Besides its potent antiviral activity, IFN-α exerts a variety of immunomodulatory effects, including positive and negative regulation of its own production, regulation of IL-12 and IFN-γ production, promotion of natural killer (NK) cell cytotoxicity, activation and maturation of dendritic cells, and the promotion of B cell development towards plasma cells.2,3 IFN-α is expressed predominantly by CD123+CD11c–CD303 (BDCA2)+ plasmacytoid dendritic cells, also referred to as natural IFN–producing cells. These cells, representing approximately 0.4% of total PBMCs, produce up to 1000-fold more type I IFNs than any other cell type. However, biologically relevant levels of IFN-α are also produced by other cell types, e.g., monocytes and myeloid dendritic cells.4 |
