Neural Crest Stem Cell MicroBeads, human
货号：
130-097-127 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-097-127 |
| 描述 | The Neural Crest Stem Cell MicroBeads were developed for the positive selection or depletion of neural crest stem cells differentiated from pluripotent stem cells. A method for in vitro differentiation of neural crest stem cells from human iPS cells is available in the library section. |
性能| 供应商 | Miltenyi |
| 背景 | CD271, also known as LNGFR (low-affinity nerve growth factor receptor), NGFR (nerve growth factor receptor), or p75NTR (neurotrophin receptor), belongs to the tumor necrosis factor receptor superfamily. CD271 was initially described to be expressed on cells of the nervous system and was suggested to be involved in the development, survival and differentiation of neural cells.1 CD271 can be found in the central and peripheral nervous system on autonomic and sensory neurons2 as well as on glial cells, including oligodendrocytes3, astrocytes4, Schwann cells5,6, and neural crest stem cells7. Neural crest stem cells can be induced from pluripotent stem cells by synergistic action of two inhibitors of SMAD signaling, Noggin and SB4315428,9 or alternatively, by a single small molecule dorsomorphin blocking signalling of several (TGF-β) superfamily receptors10. CD271+ neural crest stem cells can be selected ten days post-induction. They show expression of typical neural crest markers (HNK1, AP2) and they can be differentiated to homogenous peripheral neurons11. |
