CD207 (Langerin) MicroBeads, human
货号：
130-097-898 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-097-898 |
| 描述 | CD207 (Langerin) MicroBeads were developed for the isolation of CD207+ dendritic cells from single-cell suspensions of human epidermis. |
性能| 供应商 | Miltenyi |
| 背景 | Langerin (CD207 antigen), a 40 kDa, glycosylated type II transmembrane C-type lectin receptor, is described as the state-ofthe-art marker for identifying Langerhans cells (LCs) in humans and mice (1). LCs are a subset of dendritic cells (DCs) cells that reside in epithelia; the best studied example of these antigen-presenting cells are LCs of the epidermis. Their unique identifying feature are organelles called Birbeck Granules (BGs), which can be detected by electron microscopy. CD207 is expressed at both the surface membrane and in the cytoplasmatic BGs. CD207 plays a role as an endocytic receptor. It is directly involved in antigen capture and its endocytosis and induces the formation of BGs in immature DCs (2). |
