VISTA (D1L2G™) XP® Rabbit mAb (PE Conjugate)
货号：
18946S 基本售价：
4264.0 元 规格：
100ul
产品信息
概述| 货号 | 18946S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit IgG |
| 应用 | F |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 背景 | VISTA (V-Domain Ig Suppressor of T Cell Activation) is a negative checkpoint control protein that regulates T cell activation and immune responses. VISTA, which contains a single Ig-like V-type domain, a transmembrane domain, and an intracellular domain, has sequence similarity to both the B7 and CD28 family members. Although primarily expressed by myeloid cells, VISTA is also expressed by CD4+, CD8+, and FoxP3+ T-cells. Thus, VISTA is described as both a ligand and a receptor (1-3). Blocking VISTA induces T-cell activation and proliferation, and potentiates disease severity in the EAE model (1). Furthermore, genetic deletion of VISTA in mice leads to spontaneous T-cell activation and chronic inflammation (4,5). In mouse models of cancer, neutralization of VISTA enhances T-cell proliferation and effector function and increases tumor infiltration, suggesting VISTA blockade could be an effective strategy for tumor immunotherapy (6,7). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of human whole blood cells stained with VISTA (D1L2G) XP® Rabbit mAb (PE Conjugate) and co-stained with CD19-Alexa Fluor® 488 and CD14-APC. VISTA is present on CD14+ monocytes (right) and shows a significant increase in intensity when compared to its isotype control (center). CD19+ B cells are negative for VISTA (left). |
