MUC1 (D9O8K) XP® Rabbit mAb (PE Conjugate)
货号：
19926S 基本售价：
4264.0 元 规格：
100ul
产品信息
概述| 货号 | 19926S |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | F |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 背景 | Mucins represent a family of glycoproteins characterized by repeat domains and dense O-glycosylation (1). MUC1 (or mucin 1) is aberrantly overexpressed in most human carcinomas. Increased expression of MUC1 in carcinomas reduces cell-cell and cell-ECM interactions. MUC1 is cleaved proteolytically, and the large ectodomain can remain associated with the small 25 kDa carboxy-terminal domain that contains a transmembrane segment and a 72-residue cytoplasmic tail (1). MUC1 interacts with ErbB family receptors and potentiates ERK1/2 activation (2). MUC1 also interacts with β-catenin, which is regulated by GSK-3β, PKCγ, and Src through phosphorylation at Ser44, Thr41, and Tyr46 of the MUC1 cytoplasmic tail (3-5). Overexpression of MUC1 potentiates transformation (6) and attenuates stress-induced apoptosis through the Akt or p53 pathways (7,8). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of HCT 116 (blue) and ZR-75-1 (green) cells using MUC1 (D9O8K) XP® Rabbit mAb (PE Conjugate). |
