| 货号 | 65583S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | F |
| 目标/特异性 | ALDH1A1 (D9Q8E) XP®Rabbit mAb (PE Conjugate) recognizes endogenous levels of total ALDH1A1 protein. |
| 使用方法 | F(1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The aldehyde dehydrogenase family is a large group of enzymes that oxidize aldehydes formed through metabolic processes to their carboxylic acids (1). ALDH1A1 is a liver cytosolic isoform of acetaldehyde dehydrogenase and is involved in the major pathway of alcohol metabolism along with alcohol dehydrogenase (2). ALDH1A1 is also known as retinal dehydrogenase 1 and is involved in retinol metabolism, converting retinol to retinoic acid (3). Recent studies suggest that control of retinoid signaling through ALDH1A1 may influence hematopoietic stem cell differentiation (4). There has been recent interest in ALDH1 isoforms as predictive biomarkers in disease. Several studies have suggested that ALDH1A1 is a potential marker for cancer stem cells and chemoresistance in several tumor types, such as melanoma (5), lung cancer (6), and glioblastoma (7). |
| 存放说明 | 4C |
| 参考文献 | 1 . Jackson, B. et al. (2011) Hum Genomics 5, 283-303. 2 . Edenberg, H.J. (2007) Alcohol Res Health 30, 5-13. 3 . Duester, G. (2000) Eur J Biochem 267, 4315-24. 4 . Chute, J.P. et al. (2006) Proc Natl Acad Sci U S A 103, 11707-12. 5 . Luo, Y. et al. (2012) Stem Cells 30, 2100-13. 6 . Huang, C.P. et al. (2013) Cancer Lett 328, 144-51. 7 . Schäfer, A. et al. (2012) Neuro Oncol 14, 1452-64. |
Flow cytometric analysis of HeLa (blue) and ACHN (green) cells using ALDH1A1 (D9Q8E) XP® Rabbit mAb (PE Conjugate). |
