β-Catenin (L54E2) Mouse mAb (PE Conjugate)
货号：
6898S 基本售价：
4060.0 元 规格：
100ul
产品信息
概述| 货号 | 6898S |
| 描述 | This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated β-Catenin (L54E2) Mouse mAb (IF Preferred) #2677. |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | F |
| 目标/特异性 | β-Catenin (L54E2) Mouse mAb (PE Conjugate) detects endogenous levels of total β-catenin protein. |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 标记 | PE |
| 背景 | β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of NCI-H28 cells (blue) and HeLa cells (green) using β-Catenin (L54E2) Mouse mAb (PE Conjugate). 使用β-Catenin (L54E2)鼠单抗（PE偶联）对NCI-H28 细胞(蓝色)和HeLa 细胞 (绿色)进行流式细胞分析。 |
