Bcl-2 (124) Mouse mAb (PE Conjugate)
货号：
26295S 基本售价：
4060.0 元 规格：
100ul
产品信息
概述| 货号 | 26295S |
| 反应种属 | Human |
| 来源宿主 | Mouse IgG1 |
| 应用 | F |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 背景 | Bcl-2 exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release (1). It has been implicated in modulating mitochondrial calcium homeostasis and proton flux (2). Several phosphorylation sites have been identified within Bcl-2 including Thr56, Ser70, Thr74, and Ser87 (3). It has been suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events (4,5). Mutation of Bcl-2 at Thr56 or Ser87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes (6). Interleukin-3 and JNK-induced Bcl-2 phosphorylation at Ser70 may be required for its enhanced anti-apoptotic functions (7). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of HT-29 cells (blue) and RL-7 cells (green) using Bcl-2 (124) Mouse mAb (PE Conjugate). |
