CD44 (156-3C11) Mouse mAb (PE Conjugate)
货号：
8724S 基本售价：
4060.0 元 规格：
100ul
产品信息
概述| 货号 | 8724S |
| 描述 | This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated CD44 (156-3C11) Mouse mAb #3570. |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | F |
| 目标/特异性 | CD44 (156-3C11) Mouse mAb detects endogenous levels of total CD44 protein. |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 标记 | PE |
| 背景 | CD44 is a type I transmembrane glycoprotein that mediates cell-cell and cell-matrix interaction through its affinity for hyaluronic acid (HA) and possibly through other parts of the extracellular matrix (ECM). CD44 is highly polymorphic, possesses a number of alternative splice variants and undergoes extensive post-translational modifications (1,2). Increased surface levels of CD44 are characteristic of T cell activation, and expression of the protein is upregulated during the inflammatory response. Interactions between CD44 and HER2 have been linked to an increase in ovarian carcinoma cell growth (1-3). CD44 interacts with ezrin, radixin and moesin (ERM), linking the actin cytoskeleton to the plasma membrane and the ECM (4-6). CD44 is constitutively phosphorylated at Ser325 in resting cells. Activation of PKC results in phosphorylation of Ser291, dephosphorylation of Ser325, disassociation of ezrin from CD44, and directional motility (4). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of HeLa cells using CD44 (156-3C11) Mouse mAb (PE Conjugate) (blue) compared to concentration-matched Mouse (G3A1) mAb IgG1 Isotype Control (PE Conjugate) #6899 (red).流式细胞仪分析Hela，所用抗体为CD44 (156-3C11) Mouse mAb (PE Conjugate) (蓝色) 与浓度匹配的Mouse (G3A1) mAb IgG1 Isotype Control (PE Conjugate) #6899做对比 (红色)。 |
