Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb (PE Conjugate)
货号：
13223S 基本售价：
4060.0 元 规格：
100ul
产品信息
概述| 货号 | 13223S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | F |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 标记 | PE |
| 背景 | The Jak-Stat signaling pathway is utilized by a large number of cytokines, growth factors, and hormones (1). Receptor-mediated tyrosine phosphorylation of Jak family members triggers phosphorylation of Stat proteins, resulting in their nuclear translocation, binding to specific DNA elements, and subsequent activation of transcription. The remarkable range and specificity of responses regulated by the Stats is determined, in part, by the tissue-specific expression of different cytokine receptors, Jaks, and Stats, as well as by the combinatorial coupling of various Stat members to different receptors (2). Stat4 is predominantly expressed in the spleen, thymus, and testis and has been most extensively investigated as the mediator of IL-12 responses (3-8). Activation of Stat4 is associated with phosphorylation at Tyr693 (9). |
| 存放说明 | 4C |
参考图片Flow cytometric analysis of NK-92 cells, starved of Human Interleukin-2 (hIL-2) #8907 (4 hr) and then either untreated (blue) or IL-12-treated (50 ng/ml, 15 min; green), using Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb (PE Conjugate). |
