| 货号 | 78909S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human/Moneky |
| 来源宿主 | Rabbit IgG |
| 应用 | F |
| 目标/特异性 | Axl (C89E7) Rabbit mAb (PE Conjugate) detects endogenous levels of total Axl protein. |
| 使用方法 | F(1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Axl, Sky, and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB (2,3). A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells (4). |
| 存放说明 | 4C |
| 参考文献 | 1 . Crosier, K.E. and Crosier, P.S. (1997) Pathology 29, 131-5. 2 . Demarchi, F. et al. (2001) J Biol Chem 276, 31738-44. 3 . Lee, W.P. et al. (2002) Oncogene 21, 329-36. 4 . Bellosta, P. et al. (1997) Oncogene 15, 2387-97. |
Flow cytometric analysis of Jurkat cells (blue) and HeLa cells (green) using Axl (C89E7) Rabbit mAb (PE Conjugate). |
