| 货号 | 97680S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | IHC-P F |
| 目标/特异性 | CXCR4 (D4Z7W) Rabbit mAb (IHC Specific) recognizes endogenous levels of total CXCR4 protein. |
| 使用方法 | IHC-P(1:800) F (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | CXCR4 is a chemokine receptor that belongs to the G protein-coupled receptor family. It is activated by a small cytokine, CXCL12, also known as stromal cell derived factor 1 (SDF-1) (1). The main function of CXCR4 is the mediation of the homing of progenitor cells in the bone marrow and their recruitment to sites of injury (2). More recently, CXCR4 has been studied, as a potential therapeutic target, in the context of autoimmune diseases (3) as well as cancer, as the receptor is involved in the regulation of migration, proliferation, and survival of cancer cells (4). |
| 存放说明 | -20C |
| 参考文献 | 1 . Blanchet, X. et al. (2012) Front Immunol 3, 175. 2 . Döring, Y. et al. (2014) Front Physiol 5, 212. 3 . Debnath, B. et al. (2013) Theranostics 3, 47-75. 4 . Teicher, B.A. and Fricker, S.P. (2010) Clin Cancer Res 16, 2927-31. |
Immunohistochemical analysis of paraffin-embedded human tonsil using CXCR4 (D4Z7W) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded Jurkat (left) and 293T (right) cell pellets using CXCR4 (D4Z7W) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human Crohns disease of the colon using CXCR4 (D4Z7W) Rabbit mAb. | |
Flow cytometric analysis of K-562 cells (blue) and Daudi cells (green) using CXCR4 (D4Z7W) Rabbit mAb. Anti-rabbit IgG (H+L), F(ab)2 Fragment (Alexa Fluor® 488 Conjugate) #4412 was used as a secondary antibody. | |
Flow cytometric analysis of human peripheral blood mononucler cells using CXCR4 (D4Z7W) Rabbit mAb (right) co-stained with anti-human CD3-APC antibody compared to concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (left). Anti-rabbit IgG (H+L), F(ab)2 Fragment (Alexa Fluor® 488 Conjugate) #4412 was used as a secondary antibody. |
