| 货号 | 2755S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP/F |
| 目标/特异性 | Fgr Antibody detects endogenous levels of total Fgr proteins. This antibody does not cross-react with other proteins. |
| 使用方法 | WB(1:1000) IP (1:50) F (1:100) |
| 供应商 | CST |
| 背景 | Fgr is a member of the Src tyrosine kinase family. It has a membrane-associated amino-terminal domain that is highly divergent from other family members, internal conserved SH2 and SH3 domains and a highly conserved carboxy-terminal tyrosine kinase catalytic domain (1,2). Tyrosine 412 is located in the activation loop, and phosphorylation of this residue is critical for the activation of Fgr tyrosine kinase activity. c-Fgr is predominantly expressed in cells of hematopoietic origin including differentiated myeloid cells, NK and B cells (3,4). Fgr plays an important role in the signaling cascade from membrane receptors lacking intrinsic tyrosine kinase activity such as Bcr, FcR, and the integrin family of receptors (5). It was demonstrated that Fgr functions as a selective inhibitor of beta2 integrin-mediated signaling and Syk kinase function in monocytes (5). |
| 存放说明 | -20C |
| 计算分子量 | 56 |
Flow cytometric analysis of Raji cells, using Fgr Antibody (blue) compared to a nonspecific negative control antibody (red).流式细胞仪分析Raji 细胞，所用抗体为Fgr Antibody (蓝色) 与非特异性对照抗体(红色)对比。 | |
Western blot analysis of Raji cell lysate, using Fgr Antibody.Western免疫印迹。用Fgr Antibody研究Raji 细胞的细胞提取液。 |
