| 货号 | 2284S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P/F |
| 目标/特异性 | Cathepsin D Antibody detects endogenous levels of preprocathepsin D, procathepsin D and the heavy chain subunit of mature cathepsin D. |
| 使用方法 | WB(1:1000) IHC-P (1:200) F (1:200) |
| 供应商 | CST |
| 背景 | Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins (1). It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively) (2). Cathepsin D may also be secreted into the cytosol during apoptosis and contribute to cleavage of substrates implicated in the apoptotic pathway (3). Numerous studies have suggested that cathepsin D plays a role in neuronal degradation and malignant transformation, particularily in breast cancer (4-9). |
| 存放说明 | -20C |
| 计算分子量 | 46, 43, 28 |
Western blot analysis of extracts from PANC1, SNB19 and MCF-7 cell lines using Cathepsin D Antibody.使用Cathepsin D 抗体对PANC1, SNB19 和MCF-7细胞提取物进行western blot分析。 | |
Flow cytometric analysis of MCF-7 cells using Cathepsin D Antibody (blue) compared to a nonspecific negative control antibody (red).使用Cathepsin D 抗体（蓝色）对比非特异性阴性对照抗体（红色）对MCF-7细胞进行流式细胞分析。 | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Cathepsin D Antibody.使用Cathepsin D 抗体对石蜡包埋的人肺癌组织进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded human Non-Hodgkins lymphoma using Cathepsin D Antibody.使用Cathepsin D 抗体对石蜡包埋的人Non-Hodgins 淋巴瘤进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded human papillary carcinoma using Cathepsin D Antibody.使用Cathepsin D 抗体对石蜡包埋的人乳头状癌组织进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded human serous adenocarcinoma using Cathepsin D Antibody.使用Cathepsin D 抗体对石蜡包埋的人血液恶性瘤进行免疫组化分析。 |
