| 货号 | 2677S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | IP/IF-IC/F |
| 目标/特异性 | β-Catenin (L54E2) Mouse mAb (IF Preferred) detects endogenous levels of total β-catenin protein. |
| 使用方法 | IP(1:50) F (1:200) IF-IC (1:200) |
| 供应商 | CST |
| 背景 | β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8). |
| 存放说明 | -20C |
| 计算分子量 | 92 |
