| 货号 | 4566S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP/F |
| 目标/特异性 | Axl (C44G1) Rabbit mAb detects endogenous levels of total Axl protein. The antibody does not cross-react with related proteins. |
| 使用方法 | WB(1:1000) IP (1:50) F (1:400) |
| 供应商 | CST |
| 背景 | Axl, Sky and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB (2,3). A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells (4). |
| 存放说明 | -20C |
| 计算分子量 | 138 |
Western blot analysis of extracts from human skeletal muscle cells (hSkMC), PAE and HUVEC cells using Axl (C44G1) Rabbit mAb.用抗Axl (C44G1)的兔源单克隆抗体对人骨骼肌细胞(hSkMC)、 PAE和 HUVEC细胞的提取物进行免疫印迹检测。 | |
Flow cytometric analysis of HUVEC cells using Axl (C44G1) Rabbit mAb (blue) compared to a nonspecific negative control antibody (red).用抗Axl (C44G1)的兔源单克隆抗体（蓝色）和非特异的阴性对照抗体（红色）对HUVEC细胞进行流式细胞术检测。 |
