| 货号 | 12632S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/F |
| 使用方法 | WB(1:1000) F (1:200) |
| 供应商 | CST |
| 背景 | Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors containing a sequence known as Forkhead box or winged helix DNA binding domain (1). The human genome contains 43 Fox proteins that are divided into subfamilies. The FoxP subfamily has four members, FoxP1 - FoxP4, which are broadly expressed and play important roles in organ development, immune response and cancer pathogenesis (2-4). The FoxP subfamily has several characteristics that are atypical among Fox proteins: their Forkhead domain is located at the carboxy-terminal region and they contain motifs that promote homo- and heterodimerization. FoxP proteins usually function as transcriptional repressors (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 45 |
Western blot analysis of extracts from COS-7 cells, mock transfected (-) or transfected with human FoxP3 (hFoxP3; +), and human thymus using FoxP3 (D8O6C) Rabbit mAb. | |
Flow cytometric analysis of human peripheral blood mononuclear cells gated on CD4+ lymphocytes, showing FoxP3 expression in CD25+ cells using FoxP3 (D6O8C) Rabbit mAb (left), and corresponding absence of signal in CD25+ cells using concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, (right). Anti-rabbit IgG (H+L), (F(ab)2) Fragment (Alexa Fluor® 488 Conjugate) #4412 was used as a secondary antibody. Refer to the product specific protocol link indicated on the datasheet. |
