| 货号 | 9304S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Mouse |
| 应用 | W/F |
| 使用方法 | WB(1:1000) F (1:50) |
| 供应商 | CST |
| 背景 | Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism and transport of nuclear pre-mRNA transcripts (1). Alternative splicing produces transcripts that encode two homologous hnRNP proteins, hnRNPA2 and hnRNPB1, from a single gene sequence (2). Studies demonstrate hnRNP A2/B1 splicing repression across multiple targets (3,4) and that both proteins can bind and protect telomere repeat sequences from DNase digestion (5,6). Altered expression of hnRNP B1 is seen in several forms of cancer, including squamous cell carcinoma, adenocarcinoma, and various forms of lung cancer (7). Over expression of hnRNP B1 may be associated with inhibition of DNA-PK activity and impaired DNA repair during early stages of cancer development (8). Autoantigens to hnRNP A2/B1 (termed RA33) are associated with rheumatoid arthritis, systemic lupus erythromatosus and mixed connective tissue disease (9-11). |
| 存放说明 | -20C |
| 计算分子量 | 34 to 36 |
Western blot analysis of extracts from various cell lines using hnRNP A2/B1 (2A2) Mouse mAb. 使用hnRNP A2/B1 (2A2) Mouse mAb鼠单抗，免疫印迹(Western blot)分析不同细胞中hnRNP A2/B1 (2A2)的蛋白水平。 | |
Flow cytometric analysis of MDA-MB-134 cells using hnRNP A2/B1 (2A2) Mouse mAb (blue) compared to a nonspecific negative control antibody (red). 与非特异阴性control antibody (red)比较，使用hnRNP A2/B1 (2A2) Mouse mAb鼠单抗 (蓝色)标记，流式细胞仪分析MDA-MB-134细胞。 |
