| 货号 | 12922S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP/F |
| 使用方法 | WB(1:1000) IP (1:50) F (1:200) |
| 供应商 | CST |
| 背景 | Syndecans are a family of type 1 transmembrane heparan sulphate proteoglycans comprising 4 members in mammals (SDC-1 to -4) (1) encoded by four syndecan genes. Syndecans are involved in embryonic development, tumorigenesis, and angiogenesis (2). The extracellular domain harbors attachment sites for heparan sulfate and chondroitin sulfate chains, facilitating interaction with an array of proteins including a plethora of growth factors. In addition, the hydrophobic C-terminal intracellular domain can interact with proteins containing a PDZ domain (2). These interactions place syndecans as important integrators of membrane signaling (3). Syndecans undergo proteolytic cleavage causing the release of their extracellular domain (shedding), converting the membrane-bound proteins into soluble molecular effectors (4). |
| 存放说明 | -20C |
| 计算分子量 | 180-250 |
Western blot analysis of extracts from U266 and RPMI 8226 cells using Syndecan 1 (D4Y7H) Rabbit mAb.使用Syndecan 1 (D4Y7H) Rabbit mAb对U266和RPMI 8226 细胞提取物进行western blot分析。 | |
Flow cytometric analysis of HEK293 cells (blue) and U266 cells (green) using Syndecan 1 (D4Y7H) Rabbit mAb. Anti-rabbit IgG (H+L), F(ab)2 Fragment (Alexa Fluor® 488 Conjugate) #4412 was used as a secondary antibody.使用Syndecan 1 (D4Y7H) Rabbit mAb对HEK293 cells (蓝色) 和 U266 cells (绿色)进行流式分析。Anti-rabbit IgG (H+L), F(ab)2 Fragment (Alexa Fluor® 488 Conjugate) #4412用作二抗。 |
