Met (11C4) Mouse mAb (Flow Specific)
货号：
5631S 基本售价：
3250.0 元 规格：
200ul
产品信息
概述| 货号 | 5631S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | F |
| 目标/特异性 | Met (11C4) Mouse mAb (Flow Specific) detects endogenous levels of total Met protein. |
| 使用方法 | F(1:50) |
性能| 供应商 | CST |
| 背景 | Met, a high affinity tyrosine kinase receptor for hepatocyte growth factor (HGF, also known as scatter factor) is a disulfide-linked heterodimer made of 45 kDa α- and 145 kDa β-subunits (1,2). The α-subunit and the amino-terminal region of the β-subunit form the extracellular domain. The remainder of the β-chain spans the plasma membrane and contains a cytoplasmic region with tyrosine kinase activity. Interaction of Met with HGF results in autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl, and PI3 kinase (3). These fundamental events are important for all of the biological functions involving Met kinase activity. The addition of a phosphate at cytoplasmic Tyr1003 is essential for Met protein ubiquitination and degradation (4). Phosphorylation at Tyr1234/1235 in the Met kinase domain is critical for kinase activation. Phosphorylation at Tyr1349 in the Met cytoplasmic domain provides a direct binding site for Gab1 (5). Altered Met levels and/or tyrosine kinase activities are found in several types of tumors, including renal, colon, and breast. Thus, Met is an attractive cancer therapeutic and diagnostic target (6,7). |
| 存放说明 | -20C |
| 计算分子量 | 145 |
参考图片Flow cytometric analysis of live Ramos cells (red) and live MKN-45 cells (blue) using Met (11C4) Mouse mAb (Flow Specific).用抗体Met (11C4) Mouse mAb (Flow Specific)对live Ramos 细胞 (红色)和 live MKN-45细胞进行流式细胞术检测。 |
