Human NKG2A Phycoerythrin MAb (Clone 131411) (100 TESTS)【科瑞奥博】

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Human NKG2A Phycoerythrin MAb (Clone 131411) (100 TESTS)

货号： FAB1059P-100 基本售价： 5373.6 元规格： 100 Tests

产品信息

概述
货号	FAB1059P-100
别名	CD159 antigen-like family member A; CD159a antigen; CD159a; C-lectin type II protein; killer cell lectin-like receptor subfamily C, member 1; Klrc1; MGC13374; natural killer cell lectin; natural killer group protein 2; NK cell receptor A; NKG2; NKG2-1/B activating NK receptor; NKG2-A; NKG2-A/B type II integral membrane protein; NKG2-A/B-activating NK receptor; NKG2-A/NKG2-B type II integral membrane protein; NKG2AMGC59791; NKG2-B
全称	Natural Killer G2A
反应种属	Human
应用	Flow Cytometry
目标/特异性	Recognizes the human NKG2A/CD94 heterodimer. It does not recognize the NKG2C/CD94 heterodimer or the CD94 homodimer.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3821 (Human); 16641 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. CD3(bright)CD56(+) T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients Sci Rep, 2016;6(0):25567. Species: Human Sample Type: Whole Cells Application: Flow IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner Authors: Romain Loyon J Immunol, 2016;197(1):85-96. Species: Human Sample Type: Whole Cells Application: Flow Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts. Authors: Picardi A, Mengarelli A, Marino M, Gallo E, Benevolo M, Pescarmona E, Cocco R, Fraioli R, Tremante E, Petti M, De Fabritiis P, Giacomini P J Exp Clin Cancer Res, 2015;34(0):98. Species: Human Sample Type: Whole Cells Application: Flow Overexpression of CD85j in TNBC patients inhibits Cetuximab-mediated NK-cell ADCC but can be restored with CD85j functional blockade. Authors: Roberti M, Julia E, Rocca Y, Amat M, Bravo A, Loza J, Colo F, Loza C, Fabiano V, Maino M, Podhorzer A, Fainboim L, Barrio M, Mordoh J, Levy E Eur J Immunol, 2015;45(5):1560-9. Species: Human Sample Type: Whole Cells Application: Flow Regulatory Dendritic Cells Restrain NK Cell IFN-gamma Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors. Authors: Spallanzani R, Torres N, Avila D, Ziblat A, Iraolagoitia X, Rossi L, Domaica C, Fuertes M, Rabinovich G, Zwirner N J Immunol, 2015;195(5):2141-8. Species: Human Sample Type: Whole Cells Application: Flow NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure. Authors: Zou Y, Bao J, Pan X, Lu Y, Liao S, Wang X, Wang G, Lin D PLoS ONE, 2015;10(8):e0134568. Species: Human Sample Type: Whole Cells Application: Flow Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1. Authors: Kruse V, Hamann C, Monecke S, Cyganek L, Elsner L, Hubscher D, Walter L, Streckfuss-Bomeke K, Guan K, Dressel R PLoS ONE, 2015;10(5):e0125544. Species: Human Sample Type: Whole Cells Application: Flow Natural killer cells are characterized by the concomitantly increased interferon-gamma and cytotoxicity in acute resolved hepatitis B patients. Authors: Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, Zhou C, Shang Q, Li W, Zhang Z, Wang F PLoS ONE, 2012;7(11):e49135. Species: Human Sample Type: Whole Cells Application: Flow Phenotype markers and cytokine intracellular production by CD8+ gammadelta T lymphocytes do not support a regulatory T profile in Behcet's disease patients and healthy controls. Authors: Clemente A, Cambra A, Munoz-Saa I, Crespi C, Pallares L, Juan A, Matamoros N, Julia MR Immunol. Lett., 2010;129(2):57-63. Species: Human Sample Type: Whole Cells Application: Flow A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function. Authors: Ogbomo H, Michaelis M, Altenbrandt B, Doerr HW, Cinatl J Biochem. Pharmacol., 2010;79(2):188-97. Species: Human Sample Type: Whole Cells Application: Flow Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil. Authors: Teixeira-Carvalho A, Fujiwara RT, Stemmy EJ, Olive D, Damsker JM, Loukas A, Correa-Oliveira R, Constant SL, Bethony JM Infect. Immun., 2008;76(12):5810-6. Species: Human Sample Type: Whole Cells Application: Flow Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients. Authors: Cai L, Zhang Z, Zhou L, Wang H, Fu J, Zhang S, Shi M, Zhang H, Yang Y, Wu H, Tien P, Wang FS Clin. Immunol., 2008;129(3):428-37. Species: Human Sample Type: Whole Cells Application: Flow Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis. Authors: Correale J, Villa A J. Neuroimmunol., 2008;195(1):121-34. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	BaF3 mouse pro-B cell line transfected with human NKG2A and CD94
生物活性	Human
标记	Phycoerythrin
背景	NKG2A is a type II transmembrane receptor having a single extracellular lectin-like domain and a cytoplasmic ITIM motif. It associates with CD94 and is expressed on NK cells and some activated T cell populations. The NKG2A/CD94 complex delivers an inhibitory signal upon recognition of its ligand, HLA-E.
运输条件	Blue Ice
存放说明	4℃
参考文献	C-type Lectin Family Development of Antibodies Specific for NKG2 Family Members Human CD Marker Products Natural Killer T (NKT) Cells NKG2 Family Receptors

参考图片

Detection of NKG2A/CD159a in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2A/CD159a PE‑conjugated Monoclonal Antibody (Catalog # FAB1059P) or (B) Mouse IgG_2A Phycoerythrin Isotype Control (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.