Human TLR7 PerCP MAb (Clone 533707) (100 TESTS)【科瑞奥博】

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Human TLR7 PerCP MAb (Clone 533707) (100 TESTS)

货号： IC5875C 基本售价： 5234.8 元规格： 100 Tests

产品信息

概述
货号	IC5875C
别名	toll-like receptor 7
全称	Toll-like Receptor 7
反应种属	Human
应用	Intracellular Staining by Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human TLR7 in direct ELISAs.
使用方法	Intracellular Staining by Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	51284 (Human); 170743 (Mouse); 317468 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission. Authors: Giugliano S, Petroff M, Warren B, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko M, Gale M, Golden-Mason L, Winn V, Rosen H J Immunol, 2015;195(8):3737-47. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant human TLR7 Met360-Leu516 Accession # Q9NYK1
生物活性	Human
标记	PerCP
背景	Toll-like receptor 7 (TLR7) is a 120 kDa (predicted, unglycosylated) type I transmembrane glycoprotein and member of the Toll-like receptor family. Human TLR7 is synthesized as a 1049 amino acid (aa) precursor that contains a 26 aa signal sequence, an 803 aa extracellular domain (ECD), a 21 aa transmembrane sequence, and a 189 aa cytoplasmic domain. Mature human TLR7 is 81% aa identical to mature mouse TLR7. TLR7 is detected in brain, placenta, spleen, stomach, small intestine, lung, and in plasmacytoid pre-dendritic cells. Functionally, TLR7 participates in the innate immune response to microbial agents.
运输条件	Blue Ice
存放说明	4℃
参考文献	BIObrief: Pattern Recognition Receptors & the Innate Immune Response IL-1 Family Innate Immunity and the Toll-like Receptor Family Interactive Pathway: Inflammasome Activation Pathways Interactive Pathway: Toll-Like receptor Signaling Pathways Mini-review: The Toll-like Receptor Family Neuroinflammation NFkB Pathway NOD-like Receptors and the Inflammasome Parturition & Surfactant Protein A Pattern Recognition Receptors Plasmacytoid Dendritic Cells Regulatory T Cells (Tregs) TLR4: Contributing to Metabolic Syndrome in Multiple Tissues Toll-Like Receptors

参考图片

Detection of TLR7 in Ramos Human Cell Line by Flow Cytometry. Ramos human Burkitts lymphoma cell line was stained with Mouse Anti-Human TLR7 PerCP‑conjugated Monoclonal Antibody (Catalog # IC5875C, filled histogram) or isotype control antibody (Catalog # IC003C, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.