| 货号 | IC6166V-100UG |
| 别名 | EOMES; eomesodermin (Xenopus laevis) homolog; Eomesodermin; t box, brain, 2; T-box brain protein 2; T-box brain2; TBR2; TBR-2; TBR2eomesodermin homolog; T-brain-2 | 全称 | Eomesodermin Homolog |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human EOMES in direct ELISAs. In direct ELISAs, no cross-reactivitywith recombinant human (rh) Brachyury, rhEOMES (aa 1-115), recombinant mouseEOMES (aa 1-126), rhTBX2, 3, 5, 6, 18, or 20 is observed. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 8320 (Human); 13813 (Mouse); 316052 (Rat) |
| 免疫原 | E. coli-derived recombinant human EOMES Gly471-Pro686 Accession # O95936 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 405 |
| 背景 | EOMES (Eomesodermin; Eo from Greek meaning “dawn”/early in mesoderm; also TBR2) is a 72 kDa member of the TBR1 subfamily, T-box family of transcription factors. It is expressed in NK and CD8+ T cells, where CTLA4 activation suppresses EOMES activation of IFN-gamma and granzyme B genes. It is also found in the embryo, where it occurs in forebrain floorplate and migrating neuroblasts at 12.5 weeks gestation. Notably, it is reported to undergo intercellular transfer in fetal Xenopus tissue destined to become mesoderm. Here, it synchronizes a multicellular commitment to a cell lineage. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
|