| 货号 | IC5385U-100UG |
| 别名 | Tbet; T-bet; TBETT-PET; TBLYM; TBLYMT-cell-specific T-box transcription factor T-bet; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; TBX21; T-PET; Transcription factor TBLYM | 全称 | T-box transcription factor TBX21 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human T-bet. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 30009 (Human); 57765 (Mouse); 303496 (Rat) |
| 免疫原 | E. coli-derived recombinant human T-bet Glu326-Asn535 Accession # Q9UL17 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 350 |
| 背景 | T-boxexpressed in T cells (T-bet), also known as T-box transcription factor TBX21, is a 62 kDa member of the T-box family of transcription factors and the Tbr1 subfamily. Human T-bet is 535 amino acids in length and contains a T-box DNA binding domain (aa 136-327). Human T-bet shares 88% aa sequence identity with mouse T-bet. T-bet is a nuclear protein highly apparent in Th1-cells. Northern blot analysis revealed that it is also expressed in lung, thymus and spleen. Functionally, T-bet controls the expression of the Th1 cytokine, IFN gamma, and initiates Th1 lineage development from naïve Th precursor cells by both activating Th1 genetic programs and by repressing the opposing Th2 programs. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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