| 货号 | IC40691N-100UG |
| 别名 | FGFR signalling adaptor; FGFR-signaling adaptor SNT; fibroblast growth factor receptor substrate 2; FRS2; FRS2A; FRS2alpha; SNT; SNT1; SNT-1FGFR substrate 2; Suc1-associated neurotrophic factor target 1 | 全称 | Fibroblast Growth Factor Receptor Substrate 2 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human FRS2 in direct ELISAs. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 10818 (Human); 327826 (Mouse) |
| 免疫原 | E. coli-derived recombinant human FRS2 Asn121-Asn449 Accession # Q8WU20 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 700 |
| 背景 | FRS2 (FGFR substrate 2; also SNT and FSR2-alpha ) is a 70‑90 kDa member of the FSR family of lipid-anchored docking proteins. It is an intermediary between FGF and TRK receptors, and their Ras/MAPK signaling cascades. Human FRS2 is 512 amino acids (aa) in length. It contains a membrane-anchoring myristoylation signal (aa 1‑6), a PTB domain that interacts with FGF and NGF receptors (aa 13‑115), and a C-terminal Tyr-rich region that serves as a docking site for Grb2 and Shp2 (aa 196‑471). One splice form shows a deletion of the C-terminal four amino acids. Over aa 121‑449, human FRS2 is 99% and 94% aa identical to dog and mouse FRS2, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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