Human TM4SF1/L6 Alexa Fluor 488 Antibody (Clone 877621) (100 UG)【科瑞奥博】

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Human TM4SF1/L6 Alexa Fluor 488 Antibody (Clone 877621) (100 UG)

货号： FAB8164G-100UG 基本售价： 5086.1 元规格： 100 UG

产品信息

概述
货号	FAB8164G-100UG
别名	L6; M3s1; M3S1Tumor-associated antigen L6; Membrane component chromosome 3 surface marker 1; membrane component, chromosome 3, surface marker 1; TAAL6; TAAL6H-L6; TM4SF1; transmembrane 4 L six family member 1; transmembrane 4 L6 family member 1; transmembrane 4 superfamily member 1
全称	Transmembrane 4 L Six Family Member 1
应用	Flow Cytometry
目标/特异性	Detects human TM4SF1/L6 in ELISA. In Flow Cytometry, it stains HEK293 cells transfected with human TM4SF1/L6, and does not stain HEK293 cells transfected with irrelevant human cell surface marker.
使用方法	Flow Cytometry: 0.25-1 µg/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能

供应商

R&D Systems

Entrez Gene IDs

4071 (Human); 17112 (Mouse)

纯化方式

Protein A or G purified from hybridoma culture supernatant

免疫原

NS0 mouse myeloma cell line transfected with human TM4SF1/L6
Met1-Cys202
Accession # P30408

生物活性

Human

标记

Alexa Fluor 488

背景

TM4SF1 (Transmembrane 4 L6 family Member 1; also L6 and M3s1) is a 23-28 kDa member of the L6 tetraspanin family of molecules. It is expressed by fibroblasts, endothelial cells and a variety of tumor cells. TM4SF1 is embedded in both the plasma membrane and the membrane of late endocytic organelles. Here, it appears to be ubiquitinated, and to regulate endocytosis, an action that impacts effective cell migration. TM4SF1 is reported to interact with alpha 5 and beta 1 integrins, and this may impact cell motility. It also suppresses the expression of CD63 and CD82, two molecules that impede cell mobility. Mouse TM4SF1 is a 202 amino acid (aa) 4‑transmembrane (TM) glycoprotein. It contains a short N-terminal cytoplasmic region (aa 1-9), followed by four TM regions and another C-terminal cytoplasmic region (aa 183-202). There is one potential isoform variant that shows an alternative start site at Met60. Over aa 116-161, mouse TM4SF1 shares 73% and 96% aa sequence identity with human and rat TM4SF1, respectively.

运输条件

Blue Ice

存放说明

4℃

参考文献

Cancer Biomarkers

参考图片

Detection of TM4SF1/L6 in A549 Human Cell Line by Flow Cytometry A549 human lung carcinoma cell line was stained with Mouse Anti-Human TM4SF1/L6 Alexa Fluor® 488‑conjugated Monoclonal Antibody (Catalog # FAB8164G, filled histogram) or isotype control antibody (Catalog # IC002G, open histogram). View our protocol for Staining Intracellular Molecules.