| 货号 | FAB4139R-100UG |
| 别名 | ACKR1; CCBP1; CD234 antigen; CD234; DARC; Dfy; Duffy Antigen; Duffy antigen/chemokine receptor; Duffy blood group antigen; Duffy blood group, chemokine receptor; Fy Antigen; Fy glycoprotein; FYDuffy blood group; Glycoprotein D; GPD; GPDWBCQ1; GpFy; Plasmodium vivax receptor | 全称 | Duffy Antigen, Receptor For Chemokines |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human DARC. Stains human DARC transfected cells but not irrelevant transfectants. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 2532 (Human); 13349 (Mouse) |
| 免疫原 | HEK293 human embryonic kidney cell line transfected with human DARC Met1-Ser336 Accession # Q16570 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 647 |
| 背景 | Duffy Antigen Receptor for Chemokines (DARC), also known as Fy glycoprotein and CD234, is a 7TM non-signaling chemokine receptor that is expressed on venular endothelial cells and erythrocytes. DARC binds and mediates the internalization of several inflammatory CC and CXC chemokines. It transports chemokines to the lumenal face of venular endothelium to promote the extravasation of leukocytes to sites of inflammation. DARC polymorphisms are important in blood transfusion compatibility and determine the susceptibility of erythrocytes to Plasmodium vivax infection. Human DARC shares 60% amino acid sequence identity with mouse DARC. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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