| 货号 | FAB1559S-100UG |
| 别名 | CADASIL; CASILneurogenic locus notch homolog protein 3; Notch (Drosophila) homolog 3; notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human Notch-3 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinanthuman (rh) Notch-3 ICD (aa 2195-2321), rhNotch-1, rhNotch-1 ICD (aa 2251-2556),rhNotch-2, rhNotch-2 ICD (aa 2063-2413), rhNotch-4, rhNotch-4 ICD (aa1778-2003), recombinant mouse Notch-3, or recombinant rat DLL1 is observed. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4854 (Human); 18131 (Mouse) |
| 免疫原 | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Notch-3 Ala40-Glu467 Accession # Q9UM47 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 750 |
| 背景 | Human Notch-3 is a member of the Notch family of type I transmembrane glycoproteins involved in early-event developmental processes. The 2321 amino acid (aa) Notch-3 precursor contains a 1603 aa extracellular region with 34 EGF-like repeats. Repeats 1-11 of human Notch-3 are within the sequence used as an immunogen, and share 94% aa identity with mouse and rat Notch-3. Repeats 11 and 12 are critical for binding the ligands Jagged and Delta. Notch-3 is expressed in vascular smooth muscle, proliferating neuroepithelium, CD4-CD8- thymocytes, regulatory T cells and T-ALL leukemia cells. Mutations in the first 5 EGF repeats of Notch-3 in humans can cause CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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