| 货号 | FAB1505R-100UG |
| 别名 | ADCAD2; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP6; LRP-6 | 全称 | LDL Receptor-related Protein 6 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human LRP-6 in direct ELISAs. In direct ELISAs, approximately 5% cross-reactivitywith recombinant mouse (rm) LRP-6 and no cross-reactivity with recombinanthuman (rh) LRP-1, -4, -5, rhLRP-6 (intracellular domain), or rhLDL R isobserved. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4040 (Human); 16974 (Mouse) |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human LRP-6 Ala20-Pro1368 Accession # O75581 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 647 |
| 背景 | LRP-6 (Low-density lipoprotein receptor-related protein 6) is a 200-210 kDa member of the LDLR family of proteins. It is widely expressed, and serves as a coreceptor for both Wnt and parathyroid hormone. In the Wnt system, LRP-6 associates with select Fzd multipass receptors; in the PTH system, LRP-6 complexes with PTH1R. Mature human LRP-6 is a 1594 amino acid (aa) type I transmembrane glycoprotein. It contains a 1351 aa extracellular region (aa 20-1370) plus a 220 aa cytoplasmic domain (aa 1394-1613). The cytoplasmic domain contains two palmitoylation sites, one ubiquitination residue, and multiple phosphorylation motifs. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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