Human VEGF R3/Flt-4 Allophycocyanin MAb (Clone 54733) (100 TESTS)【科瑞奥博】

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Human VEGF R3/Flt-4 Allophycocyanin MAb (Clone 54733) (100 TESTS)

货号： FAB3492A 基本售价： 5086.1 元规格： 100 Tests

产品信息

概述
货号	FAB3492A
别名	EC 2.7.10; EC 2.7.10.1; FLT4; Flt-4; fms-related tyrosine kinase 4; LMPH1A; PCLFLT41; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; Tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; VEGFR-3; VEGFR3Fms-like tyrosine kinase 4
全称	Vascular Endothelial Growth Factor Receptor 3
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human VEGF R3/Flt-4 in direct ELISAs.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	2324 (Human); 14257 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Growth-factor-driven rescue to receptor tyrosine kinase (RTK) inhibitors through Akt and Erk phosphorylation in pediatric low grade astrocytoma and ependymoma. Authors: Sie M, den Dunnen W, Lourens H, Meeuwsen-de Boer T, Scherpen F, Zomerman W, Kampen K, Hoving E, de Bont E PLoS ONE, 2015;10(3):e0122555. Species: Human Sample Type: Whole Cells Application: Flow Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells. Authors: Norton, Kerri-An, Han, Zheyi, Popel, Aleksand, Pandey, Niranjan Onco Targets Ther, 2014;7(0):1571-82. Species: Human Sample Type: Whole Cells Application: Flow Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib. Authors: Fiorio Pla, Alessand, Brossa, Alessia, Bernardini, Michela, Genova, Tullio, Grolez, Guillaum, Villers, Arnaud, Leroy, Xavier, Prevarskaya, Natalia, Gkika, Dimitra, Bussolati, Benedett BMC Cancer, 2014;14(0):939. Species: Human Sample Type: whole cells Application: Flow Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors. Authors: Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV Oncogene, 2010;29(20):2938-49. Species: Human Sample Type: Whole Cells Application: Flow VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms. Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES Eur. J. Cancer, 2010;46(5):974-82. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human VEGF R3/Flt-4 Tyr25-Ile776 Accession # P35916
生物活性	Human
标记	Allophycocyanin
背景	VEGF R2 (KDR/Flk-1), VEGF R1 (Flt-1) and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGF R1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. VEGF R3 cDNA encodes a 1298 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGF R3 is composed of a 751 aa residue extracellular domain, a 22 aa residue transmembrane domain, and a 482 aa residue cytoplasmic domain. Both VEGF-C and VEGF-D have been shown to bind and activate VEGF R3 (Flt-4). VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.
运输条件	Blue Ice
存放说明	4℃
参考文献	Ferra, N. and R. Davis-Smyth (1997) Endocrine Reviews 18:4.

参考图片

Detection of VEGF R3/Flt‑4 in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Mouse Anti-Human VEGF R3/Flt‑4 APC‑conjugated Monoclonal Antibody (Catalog # FAB3492A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.