概述| 货号 | FAB8195A |
| 别名 | Ascites sialoglycoprotein; ASGP; HSA276359; MUC-4; mucin 4, cell surface associated; mucin 4, tracheobronchial; mucin-4; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin |
全称 | Mucin 4, Cell Surface-associated | | 反应种属 | Human |
| 应用 | Flow Cytometry(10 µL/106cells)
|
| 目标/特异性 | Detects human MUC-4 in ELISAs. |
| 使用方法 | Flow Cytometry: 10 µL/106cells
|
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 4585 (Human); 140474 (Mouse) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | E. coli-derived recombinant human MUC-4
Accession # Q99102 |
| 生物活性 | Human |
| 标记 | Allophycocyanin |
| 背景 | MUC-4 (Mucin-4), also called ASGP (ascites sialoglycoprotein) is a highly glycosylated type I transmembrane glycoprotein that may be up to 950 kDa in its full-length, fully glycosylated form. Human MUC-4 cDNA encodes 2169 amino acids (aa) with a 28 aa signal sequence and a cleavage site that creates a 1416 aa soluble, extracellular alpha chain and a 725 aa single-pass transmembrane beta chain. Between aa 1072-1317 within the alpha chain, human MUC-4 shares 69% aa sequence identity with mouse and rat MUC-4. At least 14 soluble or transmembrane splice variants of 1102-2117 aa have been described, 5 of which contain the full sequence used as an immunogen. MUC-4 can serve as a ligand for the oncogenic receptor ErbB2 and a modulator of its phosphorylation and signaling. MUC-4 is frequently aberrantly expressed in epithelial tumors and can promote tumor growth and metastasis. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Cancer Biomarkers
- Epithelial Cell Markers and Intracellular Molecules
- Epithelial Cell Polarity
- Special Glycoproteins
- Surface Ectodermal Cells
|
参考图片Detection of MUC‑4 in MCF‑7 Human Cell Line by Flow Cytometry. MCF‑7 human breast cancer cell line was stained with Mouse Anti-Human MUC‑4 APC‑conjugated Monoclonal Antibody (Catalog # FAB8195A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins. |
