| 货号 | FAB5920A |
| 别名 | 4F2; 4F2hc; 4T2HC; antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43,4F2HC; CD98 antigen; CD98 heavy chain; CD98; CD98HC; heavy chain; Lymphocyte activation antigen 4F2 large subunit; MDU1antigen defined by monoclonal 4F2, heavy chain; monoclonal 44D7; NACAE4F2 cell-surface antigen heavy chain; SLC3A2; solute carrier family 3 (activators of dibasic and neutral amino acidtransport), member 2,4F2 heavy chain antigen |
| 反应种属 | Human |
| 应用 | Flow Cytometry(10 µL/106cells) |
| 目标/特异性 | Detects human CD98 in direct ELISAs. |
| 使用方法 | Flow Cytometry: 10 µL/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 6520 (Human); 17254 (Mouse) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Chinese hamster ovary cell line CHO-derived recombinant human CD98 Asp105-Gln529 Accession # P08195 |
| 生物活性 | Human |
| 标记 | Allophycocyanin |
| 背景 | CD98, also known as 4F2hc, is a ubiquitously expressed, 85-95 kDa member of the SLC3 (solute carrier 3) family of amino acid transporters. It is a type II transmembrane glycoprotein that covalently-associates with a variable number of small, 38-45 kDa, 12-transmembrane proteins that belong to the SLC7 family of molecules. The 120-130 kDa heterdimeric 4F2 complex is known to transport neutral or cationic amino acids with, or without, a contribution of sodium. It also interacts with Integrin beta 1 and beta 3 to promote cell polarization and migration. Notably, CD98 is "vertebrate-restricted," and its appearance evolutionarily has been linked to the onset of tumorigenesis. Over amino acids (aa) 105-529, human and mouse CD98 share 76% aa sequence identity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
|
Detection of CD98 in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human CD98 APC‑conjugated Monoclonal Antibody (Catalog # FAB5920A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins. |
