Human MICA Allophycocyanin MAb (Clone 159227) (100 TESTS)【科瑞奥博】

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Human MICA Allophycocyanin MAb (Clone 159227) (100 TESTS)

货号： FAB1300A-100 基本售价： 4947.3 元规格： 100 Tests

产品信息

概述
货号	FAB1300A-100
别名	FLJ60820; MGC111087; PERB11.1
全称	MHC Class I-related Protein A
反应种属	Human
应用	Flow Cytometry
目标/特异性	Detects human MICA in direct ELISAs and Western blots. In direct ELISAs, this antibody does not cross-react with recombinant human MICB.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	100507436 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation. Authors: Leung W, Vong Q, Lin W, Janke L, Chen T, Leung W J Exp Med, 2013;210(12):2675-92. Species: Human Sample Type: Whole Cells Application: Flow Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. Authors: Madrid, Alexis S, Ganem, Don J Virol, 2012;86(16):8693-704. Species: Human Sample Type: Whole Cells Application: Flow Biomarkers on melanoma patient T cells associated with ipilimumab treatment. Authors: Wang W, Yu D, Sarnaik A, Yu B, Hall M, Morelli D, Zhang Y, Zhao X, Weber J J Transl Med, 2012;10(0):146. Species: Human Sample Type: whole cells Application: Flow Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC. Authors: Inagaki A, Ishida T, Yano H, Ishii T, Kusumoto S, Ito A, Ri M, Mori F, Ding J, Komatsu H, Iida S, Ueda R Int. J. Cancer, 2009;125(1):212-21. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	BaF3 mouse pro-B cell line transfected with human MICA
生物活性	Human
标记	Allophycocyanin
背景	MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig-like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin. The genes encoding these proteins are found within the Major Histocompatibility Complex on human chromosome 6. The MICA locus is highly polymorphic with more than 50 recognized human alleles. MICA is absent from most cells but is frequently expressed in epithelial tumors and can be induced by bacterial and viral infections. MICA is a ligand for human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma δ T cells, and CD8⁺ alpha beta T cells. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.
运输条件	Blue Ice
存放说明	4℃
参考文献	ICC / IHC Images: MICA Mini-review: NKG2D and its Ligands Natural Killer T (NKT) Cells

参考图片

Detection of MICA in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human MICA APC‑conjugated Monoclonal Antibody (Catalog # FAB1300A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.