Human Tie-2 Allophycocyanin MAb (Clone 83715) (100 TESTS)【科瑞奥博】

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Human Tie-2 Allophycocyanin MAb (Clone 83715) (100 TESTS)

货号： FAB3131A 基本售价： 4808.5 元规格： 100 Tests

产品信息

概述
货号	FAB3131A
别名	angiopoietin-1 receptor; CD202b antigen; CD202b; EC 2.7.10; EC 2.7.10.1; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; TEK tyrosine kinase, endothelial; TEK; TIE-2; TIE2CD202b; Tunica interna endothelial cell kinase; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; venous malformations, multiple cutaneous and mucosal; VMCM; VMCM1
全称	Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains 2
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human Tie-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Tie‑1, recombinant mouse Tie-2, or recombinant zebrafish Tie-2 is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	7010 (Human); 21687 (Mouse); 30747 (Zebrafish)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis Authors: Rita Campanelli PLoS ONE, 2016;11(6):e0156990. Species: Human Sample Type: Whole Cells Application: Flow Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib. Authors: Fiorio Pla, Alessand, Brossa, Alessia, Bernardini, Michela, Genova, Tullio, Grolez, Guillaum, Villers, Arnaud, Leroy, Xavier, Prevarskaya, Natalia, Gkika, Dimitra, Bussolati, Benedett BMC Cancer, 2014;14(0):939. Species: Human Sample Type: whole cells Application: Flow TGFbeta inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy. Authors: Wang C, Tang X, Sun X, Miao Z, Lv Y, Yang Y, Zhang H, Zhang P, Liu Y, DU L, Gao Y, Yin M, Ding M, Deng H Cell Res., 2012;22(1):194-207. Species: Human Sample Type: Whole Cells Application: Flow Immunophenotypic characterization of human monocyte subsets: possible implications for cardiovascular disease pathophysiology. Authors: Shantsila E, Wrigley B, Tapp L, Apostolakis S, Montoro-Garcia S, Drayson MT, Lip GY J. Thromb. Haemost., 2011;9(5):1056-66. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human Tie‑2 Ala23-Lys745 Accession # AAA61139
生物活性	Human
标记	Allophycocyanin
背景	Tie-1/Tie (tyrosine kinase with Ig and EGF homology domains 1) and Tie-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), which bind Tie-2 with high-affinity have been identified. Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.
运输条件	Blue Ice
存放说明	4℃
参考文献	Partanen, J. and D.J. Dumont (1999) Curr. Top. Microbiol. Immunol. 237:159. Takakura, N. et al. (1998) Immunity 9:677. Procopio, W. et al. (1999) J. Biol. Chem. 274:30196.

参考图片

Detection of Tie‑2 in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Mouse Anti-Human Tie‑2 APC-conjugated Monoclonal Antibody (Catalog # FAB3131A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.