Human TRANCE/RANK L Allophycocyanin MAb (Clone 685857) (100 TESTS)【科瑞奥博】

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Human TRANCE/RANK L Allophycocyanin MAb (Clone 685857) (100 TESTS)

货号： FAB6264A 基本售价： 4808.5 元规格： 100 Tests

产品信息

概述
货号	FAB6264A
别名	CD254 antigen; CD254; ODF; OPGL; OPGLOPTB2; Osteoclast differentiation factor; Osteoprotegerin ligand; RANK L; RANKLreceptor activator of nuclear factor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand; sOdf; TNF-related activation-induced cytokine; TNFSF11; TRANCEODFhRANKL2; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11
全称	TNF-related Activation-induced Cytokine
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human TRANCE/TNFSF11/RANK L in flow cytometry.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	8600 (Human); 21943 (Mouse)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human TRANCE/TNFSF11/RANK L Gly64-Asp245 Accession # AAC51762
生物活性	Human
标记	Allophycocyanin
背景	TNF-related activation-induced cytokine (TRANCE; also RANK L, OPGL, and ODF) is a 35 kDa (predicted) type II transmembrane glycoprotein and member of the TNF cytokine family. Human TRANCE is 317 amino acids (aa) in length and contains a 47 aa cytoplasmic region, a 21 aa transmembrane region, and a 249 extracellular domain (ECD), which contains two potential sites of N-linked glycosylation. Splicing variants produce three isoforms for human TRANCE. Isoform 1 is the standard form. In isoform 2, aa corresponding to 1-73 in isoform 1 are missing. In isoform 3, aa 1-47 are missing. Human TRANCE ECD is 83% identical to mouse TRANCE ECD. TRANCE is expressed highest in the peripheral lymph nodes and weaker in the spleen, peripheral blood leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach, and thyroid. TRANCE plays a role in osteoclast differentiation and activation.
运输条件	Blue Ice
存放说明	4℃
参考文献	Activated T Cells Mediate Bone Loss Through OPGL/TRANCE Human CD Marker Products ICC / IHC Images: TRANCE/TNFSF11/RANK L Multiple Myeloma Osteoblast and Osteoclast Markers Osteoclast Co-stimulation Regulatory T Cells (Tregs) T Cell Cytokine Signaling TNF Superfamily TNF Superfamily Ligands

参考图片

Detection of TRANCE/TNFSF11/RANK L in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) treated with PHA for were stained with Mouse Anti-Human IL‑2 R alpha PE‑conjugated Monoclonal Antibody (Catalog # FAB1020P) and either (A) Mouse Anti-Human TRANCE/TNFSF11/RANK L APC‑conjugated Monoclonal Antibody (Catalog # FAB6264A) or (B) Mouse IgG_2B Allophycocyanin Isotype Control (Catalog # IC0041A). View our protocol for Staining Membrane-associated Proteins.