Human MDL-1/CLEC5A Allophycocyanin MAb (Clone 283834) (100 TESTS)【科瑞奥博】

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Human MDL-1/CLEC5A Allophycocyanin MAb (Clone 283834) (100 TESTS)

货号： FAB2384A 基本售价： 4808.5 元规格： 100 Tests

产品信息

概述
货号	FAB2384A
别名	CLEC5A; CLECSF5; CLECSF5carbohydrate-recognition domain) lectin, superfamilymember 5; C-type lectin domain family 5, member A; C-type lectin superfamily member 5; MDL-1MGC138304; Myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1
全称	Myeloid DAP12-associating Lectin
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human MDL‑1/CLEC5A in Western blots. Does not cross-react with recombinant mouse MDL‑1.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	23601 (Human); 23845 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes Authors: RA Botting, KM Bertram, H Baharlou, KJ Sandgren, J Fletcher, JW Rhodes, H Rana, TM Plasto, XM Wang, JJ Lim, L Barnouti, MP Kohout, T Papadopoul, S Merten, N Olbourne, AL Cunningham, M Haniffa, AN Harman J. Leukoc. Biol, 2017;0(0):. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human MDL‑1/CLEC5A Tyr26-Lys188 Accession # Q9NY25
生物活性	Human
标记	Allophycocyanin
背景	MDL-1 is anapproximately 40 kDa transmembrane glycoprotein belonging to the C-type lectinsuperfamily. MDL-1 is expressed on immature myeloid cells, monocytes,macrophages, dendritic cells, neutrophils, NK cells, and osteocytes. Itcontains a charged lysine in the transmembrane region that enables it toassociate with DAP12 and deliver an activating signal. MDL-1 mediates inflammatory responses duringautoimmune arthritis and upon binding to Dengue and Japanese encephalitis viruses.The extracellular domain (ECD) of MDL-1 contains a juxtamembrane stalk regionand one C-type lectin domain. Within the ECD, human and mouse MDL-1 share 67%amino acid sequence identity.
运输条件	Blue Ice
存放说明	4℃
参考文献	C-type Lectin Family C-type Lectin Receptors Dendritic Cell Activation Dendritic Cell ITIM/ITAM Immunoreceptors ITIM/ITAM Immunoreceptors and Related Molecules

参考图片

Detection of MDL‑1/CLEC5A in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with (A) MouseAnti-Human Siglec-3/CD33 PE-conjugated Monoclonal Antibody (Catalog # FAB1137P) and (B) Mouse Anti-Human MDL‑1/CLEC5A APC‑conjugated Monoclonal Antibody (Catalog # FAB2384A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.