Human Factor III/Tissue Factor Allophycocyanin MAb (323519) (100 TESTS)【科瑞奥博】

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Human Factor III/Tissue Factor Allophycocyanin MAb (323519) (100 TESTS)

货号： FAB23391A 基本售价： 4808.5 元规格： 100 Tests

产品信息

概述
货号	FAB23391A
别名	CD142 antigen; CD142; coagulation factor III (thromboplastin, tissue factor); Coagulation factor III; F3; FLJ17960; TF; TFA; Thromboplastin; Tissue Factor
反应种属	Human
应用	Flow Cytometry
目标/特异性	Detects human Coagulation Factor III/Tissue Factor in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse Coagulation Factor III/Tissue Factor is observed.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	2152 (Human); 14066 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles Authors: KE Happonen, S Tran, M Mörgelin, R Prince, S Calzavarin, A Angelillo-, B Dahlbäck J. Biol. Chem., 2016;291(20):10586-601. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human Coagulation Factor III/Tissue Factor Gly34-Glu251 Accession # P13726
生物活性	Human
标记	Allophycocyanin
背景	Coagulation Factor III/Tissue Factor (TF), also known as thromboplastin and CD142, is an integral membrane protein found in a variety of cell types. It functions as a protein cofactor/receptor of Coagulation Factor VII, which is synthesized in the liver and circulated in the plasma (1). Upon binding of TF, the inactive factor VII is rapidly converted into activated VIIa. The resulting 1:1 complex of VIIa and TF initiates the coagulation pathway and has also important coagulation-independent functions such as angiognesis (2). Synthesized as a 295 amino acid precursor, TF consists of a signal peptide (residues 1-32) and the mature chain (residues 33-295). As a type I membrane protein, it contains a transmembrane region (residues 252-274) and a cytoplasmic tail (residues 275-295) (3-6).
运输条件	Blue Ice
存放说明	4℃
参考文献	Morrissey, J.H. (2004) in Handbook of Proteolytic Enzymes. Barrett, A.J. et al. (ed) San Diego, Academic Press, p. 1659. Versteeg, H.H. et al. (2003) Carcinogenesis 24:1009. Scarpati, E.M. et al. (1987) Biochemistry 26:5234. Fisher, K.L. et al. (1987) Thromb. Res. 48:89. Morrissey, J.H. et al. (1987) Cell 50:129. Spicer, E.K. (1987) Proc. Natl. Acad. Sci. USA 84:5148.

参考图片

Detection of Coagulation Factor III/Tissue Factor in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD14 PE‑conjugated Monoclonal Antibody (Catalog # FAB3832P) and either (A) Mouse Anti-Human Coagulation Factor III/Tissue Factor APC‑conjugated Monoclonal Antibody (Catalog # FAB23391A) or (B) Mouse IgG₁ Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.