| 货号 | FAB2946A |
| 简介 | Clone 687317 was used by HLDA to establish CD designation |
| 别名 | CD371; CLEC12A; CLL1; CLL-1; C-type lectin domain family 12, member A; DCAL-2; MICL | 全称 | Myeloid Inhibitory C-type Lectin-like Receptor |
| 反应种属 | Human |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human MICL/CLEC12A in direct ELISAs. In direct ELISAs, no cross-reactivitywith recombinant human (rh) CLEC1, 2, 2A, 3B, 9A, 10A, 12B, 14A,rhCD302/CLEC13A recombinant mouse (rm) CLEC4B2, or rmMICL is observed. |
| 使用方法 | Flow Cytometry: 10 µL/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 160364 (Human); 232413 (Mouse) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human MICL/CLEC12A Thr67-Ala265 Accession # Q5QGZ9 |
| 生物活性 | Human |
| 标记 | Allophycocyanin |
| 背景 | Human MICL (myeloid inhibitory C-type lectin-like receptor; also CLL-1 and KLRL-1) is a 75 kDa member of the group V C-type lectin-like receptor family of molecules. Group V molecules have a lectin-type domain that binds non-sugar ligands. MICL is a 265 amino acid (aa) type II transmembrane (TM) glycoprotein that contains a 200 aa extracellular domain (ECD). Multiple isoforms of MICL are reported. One potentially utilizes an alternate start site that adds 10 aa to the cytoplasmic domain. There is one potential soluble form that lacks the TM segment, and two truncated ECD isoforms. Human MICL ECD is 53%, 65%, and 55% aa identical to the ECD in mouse, dog and cow, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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Detection of MICL/CLEC12A in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human MICL/CLEC12A APC‑conjugated Monoclonal Antibody (Catalog # FAB2946A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins. |
