| 货号 | IC9217G-100UG |
| 简介 | Recombinant Monoclonal Antibody |
| 别名 | CDC47 homolog; CDC47; CDC47P85MCM; DNA replication licensing factor MCM7; EC 3.6.4.12; homolog of S. cerevisiae Cdc47; MCM2; MCM2PNAS146; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae); MCM7; minichromosome maintenance complex component 7; minichromosome maintenance deficient (S. cerevisiae) 7; minichromosome maintenance deficient 7; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104; Protein Phosphatase 1 | 全称 | Minichromosome Maintenance Protein 7 |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human MCM7 in direct ELISAs and Western blots. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4176 (Human); 17220 (Mouse); 288532 (Rat) |
| 免疫原 | E. coli-derived recombinant human MCM7 Gly188-Ala328 Accession # P33993 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 488 |
| 背景 | MCM7/minichromosome maintenance complex component 7, is ahighly conserved mini-chromosome maintenance protein, with ATP binding, DNAhelicase activity and single-stranded DNA binding. MCM7 forms a hexamericprotein complex with MCM2, 4 and 6proteins that has DNA helicase activity essential for the initiation of genereplication. MCM7 also binds to RAD17 tomediate ATR recruitment to damaged DNA. MCM7 expression is repressed inquiescent cells but induced in late G1 to S phase by growth factorstimulation. It is up-regulated in manycancers including colorectal, T cell lymphomas, glioblastoma, and hasprognostic value for hepatocellular carcinoma and gastric adenocarcinoma. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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