| 货号 | IC46991V-100UG |
| 别名 | EC 2.7.10; Jak3; JAK3_HUMAN; JAK-3EC 2.7.10.2; JAKL; JAKLtyrosine-protein kinase JAK3; Janus kinase 3Leukocyte janus kinase; LJAK; L-JAKJanus kinase 3 (a protein tyrosine kinase, leukocyte) |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human Jak3 in direct ELISAs. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3718 (Human); 16453 (Mouse); 25326 (Rat) |
| 免疫原 | E. coli-derived recombinant human Jak3 Gly46-Thr209 Accession # P52333 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 405 |
| 背景 | Janus Kinase 3 (Jak3) belongs to the Jak family of protein tyrosine kinases that couple to cytokine receptors and are activated by ligand binding to these receptors. Also known as Leukocyte Janus Kinase (LJak), Jak3 is activated after binding to the gamma chain of Interleukin receptors, specifically the IL-2 and IL-4 receptors. Activation of Jak3 is associated with the rapid tyrosine phosphorylation of STAT proteins. Defects in Jak3 cause an autosomal severe combined immunodeficiency disease (SCID). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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