| 货号 | FAB8910T-100UG |
| 别名 | EVR5; Leukemia-associated protein with a CXXC domain; methylcytosine dioxygenase TET1; NET2; NET-2; ten-eleven translocation-1; tetraspanin-12; TM4SF12; TSPAN12 | 全称 | Tetraspanin 12 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human TSPAN12 in direct ELISAs. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | Store the unopened product at 2 - 8 °C. Do not use past expiration date. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 23554 (Human); 269831 (Mouse); 362326 (Rat) |
| 免疫原 | NS0 mouse myeloma cell line transfected with human TSPAN12 Met1-Leu305 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 594 |
| 背景 | TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. They mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN12 plays a central role in retinal vascularization by regulating norrin signal transduction. TSPAN12 acts in concert with norrin to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin and stimulate LEF/TCF-mediated transcriptional programs. Defects in TSPAN12 are the cause of vitreoretinopathy exudative type 5, a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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