| 货号 | FAB73782T-100UG |
| 别名 | HSPC082; KIAA0569FLJ42816; SIP1; SIP1HSPC082; Smad-interacting protein 1; SMADIP1; SMADIP1ZFHX1BSIP-1; ZEB2; ZFHX1B; ZFX1B; zinc finger E-box binding homeobox 2; zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b |
| 应用 | Intracellular Staining by Flow Cytometry |
| 目标/特异性 | Detects human ZEB2/SIP1 in direct ELISAs. |
| 使用方法 | Intracellular Staining by Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 9839 (Human); 24136 (Mouse); 311071 (Rat) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | E. coli-derived recombinant human ZEB2/SIP1 Asn363-Lys537 Accession # O60315 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 594 |
| 背景 | SIP1 (Smad-interacting protein 1), also called ZEB2 (Zinc finger E-box-binding homeobox 2), is a nuclear transcription factor. SIP1 contains seven C2H2-type zinc finger domains within amino acids (aa) 211-334 and 999-1076, a Smad-MHZ binding domain (aa 437-487), an atypical homeobox domain (aa 644-703), and phosphorylation, sumoylation and acetylation sites. The 1214 aa SIP1 gives a calculated molecular weight of 136 kDa, but may actually appear closer to 200 kDa due to modifications. A 1190 aa isoform lacks aa 111-134. Within aa 363-537, human SIP1 shares 98% and 97% aa sequence identity with mouse and rat SIP1, respectively. SIP1 is highly expressed in postmitotic neocortical cells and influences cell fate decisions in embryonic brain development. Point mutations causing underexpression of SIP1 are associated with Mowat-Wilson syndrome (MWIS), also known as Hirschprung disease mental retardation syndrome. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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