| 货号 | FAB6704V-100UG |
| 别名 | MGC126430; MGC126431; SLEB1FLJ10052; TIL-3; TIL3Toll/interleukin-1 receptor-like protein 3; TLR5; toll-like receptor 5 | 全称 | Toll-like Receptor 5 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human TLR5 in direct ELISAs and Western blots. In Western blots, less than 5% cross-reactivity withrecombinant human (rh) TLR1, 2, 3, 4, 7, 8, recombinant mouse TLR5, 6, orrhTIRAP is observed. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 7100 (Human); 53791 (Mouse); 289337 (Rat) |
| 免疫原 | E. coli-derived recombinant human TLR5 Ile21-Phe115 Accession # O60602 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 405 |
| 背景 | TLR5 is an ~100 kDa type I transmembrane glycoprotein of the Toll-like receptor family. It is expressed on mucosal epithelia in the gastrointestinal tract, airways, and other areas of potential bacterial contact and recognizes bacterial flagellin. Expression is also reported on monocytes, immature dendritic cells, and CD4+ T lymphocytes. The region of human TLR5 used as an immunogen includes the first 2 of 16 leucine-rich repeats and shares 72% amino acid identity with mouse and rat TLR5. This region is outside of the flagellin binding region. Flagellin engagement induces dimerization and intracellular signaling via MyD88. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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