| 货号 | FAB13882U-100UG |
| 别名 | cadherin 2, N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; CD325 antigen; CD325; CDH2; CDHNcalcium-dependent adhesion protein, neuronal; CDw325; NCadherin; N-Cadherin; NCADN-cadherin 1; Neural cadherin; neural-cadherin | 全称 | Neural Cadherin |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human N-Cadherin in direct ELISAs. In direct ELISAs, approximately 25%cross-reactivity with recombinant mouse N-Cadherin is observed and nocross-reactivity with recombinant human (rh) E-Cadherin orrhCadherin-4/R-Cadherin is observed. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 1000 (Human); 12558 (Mouse); 83501 (Rat) |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human N-Cadherin Ser26-Arg159 Accession # P19022 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 350 |
| 背景 | N‑Cadherin (Neural Cadherin; also CD325 and Cadherin-2) is a 130‑135 kDa member of the "classical" (or type I) cadherin subfamily, cadherin superfamily of proteins. It is expressed on multiple cell types, including neurons, fibroblasts, Schwann cells, endothelial cells and hepatic stellate cells. N‑Cadherin mediates homotypic binding, either in cis (same cell) or trans (adjacent cell). proN‑Cadherin is expressed as an 881 amino acid (aa) type I transmembrane glycoprotein. It may be initially inserted into the ER, where the 15‑20 kDa prodomain (aa 26‑159) is cleaved by proprotein convertase, and the mature molecule is transported to the surface. Alternatively, on neurons, proN‑Cadherin may first appear on the surface, with cleavage occurring at the time of synaptogenesis. Cleavage appears necessary for homophilic interaction as presence of the prodomain is suggested to negatively regulate oligomer formation. Over the entire prodomain, the human N‑Cadherin proregion shares 87% aa identity with the mouse N‑Cadherin proregion. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
|