Human CCR2 Phycoerythrin MAb (Clone 48607) (100 TESTS)【科瑞奥博】

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Human CCR2 Phycoerythrin MAb (Clone 48607) (100 TESTS)

货号： FAB151P-100 基本售价： 4659.8 元规格： 100 Tests

产品信息

概述
货号	FAB151P-100
简介	Clone 48607 was used by HLDA to establish CD designation
别名	C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2CKR2B; CCR2; CCR-2; CCR2A; CCR2B; CD192 antigen; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CMKBR2MGC111760; FLJ78302; MCP-1 receptor; MCP-1-RMGC103828; MGC168006; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
反应种属	Human
应用	Flow Cytometry(10 µL/10⁶cells)
目标/特异性	Detects human CCR-2 transfectants but not the parental cell line or CCR-5 transfectants.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	729230 (Human); 12772 (Mouse); 60463 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes. Authors: Carvallo L, Lopez L, Che F, Lim J, Eugenin E, Williams D, Nieves E, Calderon T, Madrid-Aliste C, Fiser A, Weiss L, Angeletti R, Berman J J Immunol, 2015;194(7):3246-58. Species: Human Sample Type: Whole Cells Application: Flow CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD. Authors: Falk M, Singh A, Faber C, Nissen M, Hviid T, Sorensen T PLoS ONE, 2014;9(12):e112473. Species: Human Sample Type: whole cells Application: Flow Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. Authors: Badr G, Lefevre EA, Mohany M PLoS ONE, 2011;6(9):e23741. Species: Human Sample Type: Whole Cells Application: Flow Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH J. Immunol., 2010;184(6):2886-98. Species: Human Sample Type: Whole Cells Application: Flow Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. Authors: Rohrl J, Yang D, Oppenheim JJ, Hehlgans T J. Immunol., 2010;184(12):6688-94. Species: Human Sample Type: Whole Cells Application: Flow CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses. Authors: Carbone T, Nasorri F, Pennino D J. Immunol., 2010;184(2):1102-10. Species: Human Sample Type: Whole Cells Application: Flow The Lupane-type Triterpene 30-Oxo-calenduladiol Is a CCR5 Antagonist with Anti-HIV-1 and Anti-chemotactic Activities. Authors: Barroso-Gonzalez J, El Jaber-Vazdekis N, Garcia-Exposito L, Machado JD, Zarate R, Ravelo AG, Estevez-Braun A, Valenzuela-Fernandez A J. Biol. Chem., 2009;284(24):16609-20. Species: Human Sample Type: Whole Cells Application: Flow Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction. Authors: Tsujioka H, Imanishi T, Ikejima H, Kuroi A, Takarada S, Tanimoto T, Kitabata H, Okochi K, Arita Y, Ishibashi K, Komukai K, Kataiwa H, Nakamura N, Hirata K, Tanaka A, Akasaka T J. Am. Coll. Cardiol., 2009;54(2):130-8. Species: Human Sample Type: Whole Cells Application: Flow Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. Authors: Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D J. Immunol., 2008;181(11):8053-67. Species: Human Sample Type: Whole Cells Application: Flow C-reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes. Authors: Montecucco F, Steffens S, Burger F, Pelli G, Monaco C, Mach F J. Leukoc. Biol., 2008;84(4):1109-19. Species: Human Sample Type: Whole Cells Application: Flow Expression of CXC and CC type of chemokines and its receptors in tuberculous and non-tuberculous effusions. Authors: Pokkali S, Das SD, R L Cytokine, 2008;41(3):307-14. Species: Human Sample Type: Whole Cells Application: Flow Nonpathogenic CCR2-tropic SIVrcm after serial passage and its effect on SIVmac infection of Indian rhesus macaques. Authors: Ling B, Veazey RS, Marx PA Virology, 2008;379(1):38-44. Species: Primate - Macaca mulatta (Rhesus monkey) Sample Type: Whole Cells Application: Flow Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation. Authors: Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA J. Neuroimmunol., 2008;199(1):35-45. Species: Human Sample Type: Whole Cells Application: Flow Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling. Authors: Bestebroer J, Poppelier MJ, Ulfman LH, Lenting PJ, Denis CV, van Kessel KP, van Strijp JA, de Haas CJ Blood, 2007;109(7):2936-43. Species: Human Sample Type: Whole Cells Application: Flow Bleomycin treatment causes enhancement of virus replication in the lungs of SHIV-infected macaques. Authors: Dhillon NK, Pinson D, Dhillon S, Tawfik O, Danley M, Davis M, Nemon O, Mayo M, Kumar A, Tsai YJ, Kumar A, Buch S Am. J. Physiol. Lung Cell Mol. Physiol., 2007;292(5):L1233-40. Species: Primate - Macaca mulatta (Rhesus monkey) Sample Type: Whole Cells Application: Flow CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity. Authors: Freeman CM, Curtis JL, Chensue SW Am. J. Pathol., 2007;171(3):767-76. Species: Human Sample Type: Whole Cells Application: Flow Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy. Authors: Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K, Franken-Kunkel P, Poremba C, Snyderman C, Klotz LO, Ruzicka T, Bier H, Zlotnik A, Whiteside TL, Homey B, Hoffmann TK Int. J. Cancer, 2006;118(9):2147-57. Species: Human Sample Type: Whole Cells Application: Flow Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation. Authors: Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A Blood, 2005;105(3):931-9. Species: Human Sample Type: Whole Cells Application: Flow CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery. Authors: Gessler P, Pretre R, Hohl V, Rousson V, Fischer J, Dahinden C Shock, 2004;22(6):513-20. Species: Human Sample Type: Whole Cells Application: Flow Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Authors: Casazza S, Zappia E, Pistorio A, Gambini C Proc. Natl. Acad. Sci. U.S.A., 2004;101(30):11064-9. Species: Human Sample Type: Whole Cells Application: Flow Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A J. Leukoc. Biol., 2003;73(5):584-90. Species: Human Sample Type: Whole Cells Application: Flow Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge. Authors: Liu LY, Jarjour NN, Busse WW, Kelly EA J. Allergy Clin. Immunol., 2003;112(3):556-62. Species: Human Sample Type: BALF Application: Flow Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces. Authors: Vanbervliet B, Homey B, Durand I, Massacrier C, Ait-Yahia S, de Bouteiller O, Vicari A, Caux C Eur J Immunol, 2002;32(1):231-42. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from ascites
免疫原	NS0 mouse myeloma cell line transfected with human CCR2 Met1-Leu360 Accession # NP_001116868
生物活性	Human
标记	Phycoerythrin
背景	CCR2 is a G-protein linked seven transmembrane domain spanning chemokine receptor that preferentially binds monocyte chemoattractant proteins-1 and -3 (MCP-1 and MCP-3). Two isoforms of this receptor (CCR2A and CCR2B) are expressed on cell surfaces as a result of alternate splicing from the same gene. These two CCR2 variants differ only at their intracellular carboxyl terminals, with the CCR2A form possessing 14 additional amino acids. This may provide a mechanism by which cells responding to similar extracellular ligands can activate different intracellular second messengers. Cells that respond to the action of MCP-1 and therefore are likely to express CCR2 receptors, include monocytes, T cells, NK cells, basophils, mast cells and dendritic cells. A recent report suggests that B cells may also express CCR2 receptors. The recognition that a variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors and as facilitators of T cell recruitment during inflammation makes chemokine receptor monitoring an important exercise in elucidating the HIV infection process and the regulation of inflammatory reactions.
运输条件	Blue Ice
存放说明	4℃
参考文献	CC Chemokines and Receptors Chemokine Receptors Chemokines and Receptors in Allergy and Asthma Chemokines and Receptors in Angiogenesis Human CD Marker Products Macrophage Activation Markers Monocyte Markers Myeloid Lineage Markers Myeloid-derived Suppressor Cells (MDSC) Neuroinflammation Proinflammatory Cytokines & CCR2 Promote Estrogen-deficient Bone Loss Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Migration/Adhesion

参考图片

Detection of CCR2 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD14 APC‑conjugated Monoclonal Antibody (Catalog # FAB3832A) and either (A) Mouse Anti-Human CCR2 PE‑conjugated Monoclonal Antibody (Catalog # FAB151P) or (B) Mouse IgG_2B Phycoerythrin Isotype Control (Catalog # IC0041P). View our protocol for Staining Membrane-associated Proteins.