Human ULBP-3 Phycoerythrin MAb (Clone 166510) (100 TESTS)【科瑞奥博】

产品中心

当前位置：首页>产品中心

Human ULBP-3 Phycoerythrin MAb (Clone 166510) (100 TESTS)

货号： FAB1517P 基本售价： 4659.8 元规格： 100 Tests

产品信息

概述
货号	FAB1517P
别名	NKG2D ligand 3; RAET1N; UL16 binding protein 3
全称	UL16 Binding Protein-3
反应种属	Human
应用	Flow Cytometry
目标/特异性	Detects human ULBP-3 in ELISAs. Does not cross-react with recombinant human (rh) ULBP-1 or rhULBP-2.
使用方法	Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	79465 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Combination treatment with decitabine and ionizing radiation enhances tumor cells susceptibility of T cells Sci Rep, 2016;6(0):32470. Species: Human Sample Type: Whole Cells Application: Flow Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells. Authors: Hedlund M, Nagaeva O, Kargl D, Baranov V, Mincheva-Nilsson L PLoS ONE, 2011;6(2):e16899. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	BaF3 mouse pro-B cell line transfected with human ULBP-3
生物活性	Human
标记	Phycoerythrin
背景	ULBP-3 is a member of a family of cell-surface proteins that function as ligands for human NKG2D. ULBP-3 has also been described under the names RaeT1N (retinoic acid early transcript), NKG2DL3, and ALCAN-gamma. The name ULBP-3 derives from the original identification of three proteins, ULBP-1, -2, and -3, as ligands for the human cytomegalovirus glycoprotein UL16; they were designated UL16 binding proteins (ULBP). The gene for ULBP-3 resides in a cluster of ten related genes, six of which encode potentially functional glycoproteins. Amino acid sequence identity within this family ranges from 30‑60%. These proteins are distantly related to MHC class I proteins, but they possess only the alpha 1 and alpha 2 Ig-like domains, and they have no capacity to bind peptide or interact with beta 2‑microglobulin. Some family members, including ULBP-3, are anchored to the membrane via a GPI-linkage, whereas others have transmembrane domains. ULBP-3 and several other family members are known to bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma δ T cells, and CD8⁺ alpha beta T cells. Engagement of NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. The ULBPs are expressed on some tumor cells and have been implicated in tumor surveillance (1‑7).
运输条件	Blue Ice
存放说明	4℃
参考文献	Cosman, D. et al. (2001) Immunity 14:123. Kubin, M. et al. (2001) Eur. J. Immunol. 31:1428. Sutherland, C. et al. (2002) J. Immunol. 168:671. Steinle, A. et al. (2001) Immunogenetics 53:279. Sutherland, C. et al. (2001) Immunol. Rev. 181:185. Pende, D. et al. (2002) Cancer Res. 62:6178. Radosavljevic, M. et al. (2002) Genomics 79:114. NKG2D and its Ligands (2002) http://www.RnDSystems.com/.

参考图片

Detection of ULBP‑3 in Human monocyte-derived dendritic cells by Flow Cytometry. Human monocyte-derived dendritic cells were stained with Mouse Anti-Human ULBP‑3 PE‑conjugated Monoclonal Antibody (Catalog # FAB1517P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Detection of ULBP‑3 in BaF3 Mouse Cell Line Transfected with Human ULBP-3 by Flow Cytometry. BaF3 mouse pro-B cell line transfected with human ULBP-3 was stained with Mouse Anti-Human ULBP‑3 PE‑conjugated Monoclonal Antibody (Catalog # FAB1517P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.