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HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

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Human NKG2C Phycoerythrin MAb (Clone 134591) (100 TESTS)

货号: FAB138P-100 基本售价: 4659.8 元 规格: 100 Tests

产品信息

概述
货号FAB138P-100
别名CD159 antigen-like family member C; CD159c antigen; CD159c; killer cell lectin-like receptor subfamily C, member 2; KLRC2; MGC138244; NK cell receptor C; NKG2-C type II integral membrane protein; NKG2-C; NKG2CNKG2-C-activating NK receptor
全称Natural Killer G2C
反应种属Human
应用Flow Cytometry
目标/特异性Detects human NKG2C/CD159c heterodimer with CD94 in flow cytometry. It does not cross-react with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer.
使用方法Flow Cytometry: 10 µL/106cells
来源The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分
性能
供应商R&D Systems
Entrez Gene IDs3822 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection
Authors: Martin R Goodier
J Immunol, 2016;197(1):313-25.
Species: Human
Sample Type: Whole Cells
Application: Flow
New insights on the natural killer cell repertoire from a thorough analysis of cord blood cells
Authors: P Rettman, C Willem, G David, R Riou, N Legrand, J Esbelin, A Cesbron, D Senitzer, K Gagne, C Retière
J Leukoc Biol, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Flow
CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection
Eur J Immunol, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Flow
Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.
Authors: Marquardt N, Beziat V, Nystrom S, Hengst J, Ivarsson M, Kekalainen E, Johansson H, Mjosberg J, Westgren M, Lankisch T, Wedemeyer H, Ellis E, Ljunggren H, Michaelsson J, Bjorkstrom N
J Immunol, 2015;194(6):2467-71.
Species: Human
Sample Type: Whole Cells
Application: Flow
NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation.
Authors: Moraru M, Black L, Muntasell A, Portero F, Lopez-Botet M, Reyburn H, Pandey J, Vilches C
J Immunol, 2015;195(4):1676-84.
Species: Human
Sample Type: Whole Cells
Application: Flow
Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset.
Authors: van Meijgaarden K, Haks M, Caccamo N, Dieli F, Ottenhoff T, Joosten S
PLoS Pathog, 2015;11(3):e1004671.
Species: Human
Sample Type: Whole Cells
Application: Flow
The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education.
Authors: Marquardt N, Ivarsson M, Blom K, Gonzalez V, Braun M, Falconer K, Gustafsson R, Fogdell-Hahn A, Sandberg J, Michaelsson J
J Immunol, 2015;195(7):3262-72.
Species: Human
Sample Type: Whole Cells
Application: Flow
2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells.
Authors: Dunphy S, Guinan K, Chorcora C, Jayaraman J, Traherne J, Trowsdale J, Pende D, Middleton D, Gardiner C
Genes Immun, 2015;16(5):301-10.
Species: Human
Sample Type: Whole Cells
Application: Flow
Natural Killer p46 Controls Hepatitis B Virus Replication and Modulates Liver Inflammation.
Authors: Li W, Jiang Y, Wang X, Jin J, Qi Y, Chi X, Zhang H, Feng X, Niu J
PLoS ONE, 2015;10(8):e0135874.
Species: Human
Sample Type: Whole Cells
Application: Flow
Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts.
Authors: Picardi A, Mengarelli A, Marino M, Gallo E, Benevolo M, Pescarmona E, Cocco R, Fraioli R, Tremante E, Petti M, De Fabritiis P, Giacomini P
J Exp Clin Cancer Res, 2015;34(0):98.
Species: Human
Sample Type: Whole Cells
Application: Flow
Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring?
Authors: Castley, Alison, Berry, Cassandr, French, Martyn, Fernandez, Sonia, Krueger, Romano, Nolan, David
PLoS ONE, 2014;9(12):e115226.
Species: Human
Sample Type: Whole Cells
Application: Flow
Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients.
Authors: Achour, Abla, Baychelier, Florence, Besson, Caroline, Arnoux, Armelle, Marty, Michel, Hannoun, Laurent, Samuel, Didier, Debre, Patrice, Vieillard, Vincent
J Immunol, 2014;192(1):503-11.
Species: Human
Sample Type: Whole Cells
Application: Flow
Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.
Authors: Charoudeh H, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M
Eur J Immunol, 2013;43(2):480-7.
Species: Human
Sample Type: whole cells
Application: Flow
CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients.
Authors: Beziat V, Dalgard O, Asselah T, Halfon P, Bedossa P, Boudifa A, Hervier B, Theodorou I, Martinot M, Debre P, Bjorkstrom NK, Malmberg KJ, Marcellin P, Vieillard V
Eur. J. Immunol., 2012;42(2):447-57.
Species: Human
Sample Type: Whole Cells
Application: Flow
Natural killer cells are characterized by the concomitantly increased interferon-gamma and cytotoxicity in acute resolved hepatitis B patients.
Authors: Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, Zhou C, Shang Q, Li W, Zhang Z, Wang F
PLoS ONE, 2012;7(11):e49135.
Species: Human
Sample Type: Whole Cells
Application: Flow
Human Cytomegalovirus (CMV)-Induced Memory-like NKG2C+ NK Cells Are Transplantable and Expand In Vivo in Response to Recipient CMV Antigen.
Authors: Foley, Bree, Cooley, Sarah, Verneris, Michael, Curtsinger, Julie, Luo, Xianghua, Waller, Edmund K, Anasetti, Claudio, Weisdorf, Daniel, Miller, Jeffrey
J Immunol, 2012;189(10):5082-8.
Species: Human
Sample Type: Whole Cells
Application: Flow
Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies.
Authors: Le Garff-Tavernier M, Decocq J, de Romeuf C, Parizot C, Dutertre CA, Chapiro E, Davi F, Debre P, Prost JF, Teillaud JL, Merle-Beral H, Vieillard V
Leukemia, 2011;25(1):101-9.
Species: Human
Sample Type: Whole Cells
Application: Flow
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus.
Authors: Bjorkstrom NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaelsson J, Malmberg KJ, Klingstrom J, Ahlm C, Ljunggren HG
J. Exp. Med., 2011;208(1):13-21.
Species: Human
Sample Type: Whole Cells
Application: Flow
NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease.
Authors: Angelini DF, Zambello R, Galandrini R, Diamantini A, Placido R, Micucci F, Poccia F, Semenzato G, Borsellino G, Santoni A, Battistini L
J. Leukoc. Biol., 2011;89(1):75-84.
Species: Human
Sample Type: Whole Cells
Application: Flow
High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy.
Authors: Spanholtz J, Tordoir M, Eissens D, Preijers F, van der Meer A, Joosten I, Schaap N, de Witte TM, Dolstra H
PLoS ONE, 2010;5(2):e9221.
Species: Human
Sample Type: Whole Cells
Application: Flow
NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs.
Authors: Beziat V, Descours B, Parizot C, Debre P, Vieillard V
PLoS ONE, 2010;5(8):e11966.
Species: Human
Sample Type: Whole Cells
Application: Flow
Shaping of iNKT cell repertoire after unrelated cord blood transplantation.
Authors: Beziat V, Nguyen S, Exley M, Achour A, Simon T, Chevallier P, Sirvent A, Vigouroux S, Debre P, Rio B, Vieillard V, Lubrano-Berthelier C, Alatrakchi N
Clin. Immunol., 2010;135(3):364-73.
Species: Human
Sample Type: Whole Cells
Application: Flow
The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia.
Authors: Brunetta E, Fogli M, Varchetta S, Bozzo L, Hudspeth KL, Marcenaro E, Moretta A, Mavilio D
Blood, 2009;114(18):3822-30.
Species: Human
Sample Type: Whole Cells
Application: Flow
An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.
Authors: Dulphy N, Haas P, Busson M, Belhadj S, Peffault de Latour R, Robin M, Carmagnat M, Loiseau P, Tamouza R, Scieux C, Rabian C, Di Santo JP, Charron D, Janin A, Socie G, Toubert A
J. Immunol., 2008;181(3):2227-37.
Species: Human
Sample Type: Whole Cells
Application: Flow
Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma.
Authors: Srivastava BI, Srivastava MD
Leuk. Res., 2005;29(7):771-83.
Species: Human
Sample Type: Whole Cells
Application: Flow

纯化方式Protein A or G purified from hybridoma culture supernatant
免疫原BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
生物活性Human
标记Phycoerythrin
背景NKG2C, also known as hemoglobin scavenger receptor, is a type I transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region.
运输条件Blue Ice
存放说明4℃
参考文献
  • C-type Lectin Family
  • Development of Antibodies Specific for NKG2 Family Members
  • Human CD Marker Products
  • Natural Killer T (NKT) Cells
  • NKG2 Family Receptors
参考图片
Detection of NKG2C/CD159c in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2C/CD159c PE‑conjugated Monoclonal Antibody (Catalog # FAB138P) or (B) Mouse IgG1 Phycoerythrin Isotype Control (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.